Osteoarthritis (OA) also referred to as degenerative joint disease (DJD) is a group of joint abnormalities involving degradation of joints, including articular cartilage and subchondral bone. It is not an inflammatory disease. Symptoms may include joint pain, tenderness, stiffness, locking, clicking, and sometimes an effusion.
There are a variety of causes including hereditary, developmental, metabolic, and mechanical deficits. When bone surfaces become less well protected by cartilage, bone may be exposed and damaged. As a result of decreased movement secondary to pain, regional muscles may atrophy, and ligaments may become more lax.
This condition is a wearing away of cartilage in the hip joint caused by arthritis, which can develop because of trauma, infection, age or autoimmune disorders.
The main symptom is pain, causing loss of ability and often stiffness. “Pain” is generally described as a sharp ache or a burning sensation in the associated muscles and tendons. OA can cause a crackling noise (called “crepitus“) when the affected joint is moved or touched and people may experience muscle spasms and contractions in the tendons.
Occasionally, the joints may also be filled with fluid. Some people report increased pain associated with cold temperature or high humidity.
OA commonly affects the hands, feet, spine, and the large weight bearing joints, such as the hips and knees, although in theory, any joint in the body can be affected. As OA progresses, the affected joints appear larger, are stiff and painful, and usually feel better with gentle use but worse with excessive or prolonged use, thus distinguishing it from rheumatoid arthritis.
Diagnosis can be made based on history and clinical examination. X-rays may confirm the diagnosis. The typical changes seen on X-ray include: joint space narrowing, subchondral sclerosis (increased bone formation around the joint), subchondral cyst formation, and osteophytes. Usually other imaging techniques, such as CAT scan and MRI, are not necessary to clinically diagnose OA.
Damage from mechanical stress with insufficient self-repair by joints is believed to be the primary cause of osteoarthritis. Sources of this stress may include: misalignments of bones caused by congenital or pathogenic causes; mechanical injury; excess body weight; loss of strength in the muscles supporting a joint; and impairment of peripheral nerves, leading to sudden or uncoordinated movements. It is more among siblings, and especially identical twins. It is more prevalent among post-menopausal women than among men of the same age.
Other non-primary causes include: Alkaptonuria, congenital disorders of joints, diabetes, Ehlers Danlos Syndrome, Hemochromatosis, inflammatory diseases (such as Perthes disease), Lyme disease and all chronic forms of arthritis, injury to joints or ligaments (such as the ACL), as a result of an accident or orthopedic operations, Marfan syndrome, obesity, and septic arthritis (infection of a joint).
Treatment generally involves a multimodal approach including a combination of exercise, lifestyle modification, analgesics, joint injections and in severe cases, joint replacement surgery.
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